ABSTRACT
Objective To study the changes of serum NO, TGF-β1, IL-10 and IL-17 Levels and study of the efficacy of Bismuth - containing quadruple and standard triple therapy for patients with Hp positive peptic ulcer. Methods 109 cases of peptic ulcer treated in our hospital were retrospectively selected, and Hp test was positive. According to different dosing regimen, the patients were divided into two groups. There were 54 patients in the control group, using standard triple therapy, and the regimen was lansoprazole, amoxicillin, and metronidazole. 55 patients in the study group were treated with bismuth-based western therapy with bismuth potassium citrate, rabeprazole, amoxicillin, and furazolidone. Two weeks after treatment were regarded as the observation period, and the levels of serum NO, TGF-β1, IL-10 and IL-17 in the two groups were compared before and after treatment. The effective rate of ulcer healing, Hp clearance rate and incidence of adverse reactions were compared. Results The level of serum NO, TGF-β1, IL-10 and IL-17 was significantly lower than that in the control group (P <0.05). The effective rates of ulcer healing and Hp clearance in the study group were significantly higher than those in the control group (P <0.05). There was no significant differences between the study group and the control group in the incidence of adverse reactions. Conclusion Western medicine with bismuth in the treatment of Hp peptic ulcer patients, the serum NO, TGF-β1, IL-10 and IL-17 levels of indicators have significantly improved, and has obvious advantages in clinical treatment, and it is a reasonable dosing regimen of high efficiency and low recurrence.
ABSTRACT
[Objective]To probe into the immune protective effect of Astragalus polysaccharide on mice ,whose genital tract was infected with Chlamydia trachomatis. [Methods]After the murine model of genital tract infected with chlamydia trachomatis was established, we could obtain the minimum effective infective dose. Mice were immuned by different doses(10 mg·kg-1, 20 mg·kg-1, 40 mg·kg-1) of Astragalus polysaccharide(APS) and 0.9%NS , meanwhile the blank group was regarded as the control group. After mice were immuned, we detected serum IgG antibody levels by ELISA method,and took the twice effective dose of chlamydia trachomatis to attack the genital tract after a week. Then the mice genital shedding of epithelial cells were cultured at each interval 2d. After 10 days, we kil ed the mice to calculate spleen(thymus) index, and observed the pathological changes in the reproductive tract of the mice. [Results]Compared with the control group, spleen(thymus) index and serum IgG antibody levels of Astragalus polysaccharide group are significantly higher. The results of vaginal exfoliated cells from Ct training show that, Ct positive rate of Astragalus polysaccharide group is significantly reduced, the number of inclusion bodies is also significantly decreased. And with the increasing concentration of Astragalus polysaccharide, the protective effect is more obvious. The NS group has no significant difference from the control group in al indicators. [Conclusions]Astragalus polysaccharide can induce immune protection on Ct genital tract attacked mice, and in the concentration range, with the increase of the concentration, the protection effect is better.